Preparation of Diltiazem Basefrom Official Salt form and Its Characterization and Preparation of Matrix Type Transdermal Patch Using Diltiazem Drug

ABSTRACT

Drug delivery system may be a controlled release drug delivery system where there is predictive control over the release pattern, and subsequent tissue or blood levels can be achieved.Conventional systems of medication that require multi dose therapy are having many problems. The controlled drug delivery is a newer approach is to deliver drug in to systemic circulation at a predetermined rate. Our system should duplicate continuous intravenous infusion, which not only by passes hepatic ‘first pass’ elimination but also maintains a constant, prolonged and therapeutically effective drug level in the body. This is made possible by using intact skin as a port of drug administration to provide continuous delivery of drug in to systemic circulation. The drug molecules are then transported to the target site, which could be relatively remote from the site of administration, to produce therapeutic action.

FULL TEXT