Poloxamer-Alginate Floating Beads Containing Glimepiride Were Prepared Using Foam Technology And Evaluated In Vitro

ABSTRACT

The preparation of floating beads of anti-diabetic medication sulphonyl-urea derivatives such as glimepiride was attempted. The study includes two poloxamers, sodium alginate and poloxamer 188, which are easy and repeatable. Various polymer combinations of poloxamer were used and found to aid in the buoyancy of glimepiride beads. A total of nine glimepiride formulations were studied, utilising techniques such as organoleptic characteristics, swelling index, buoyancy, and drug entrapment. The in vitro drug release experiments indicate an acceptable performance of floating beads. Consistent findings for up to 10 hours were found via in vitro investigations of beads using a 0.1 NHC solution with a pH of 1.2. The foamability and stability were improved by using the foaming agent; the stability increased up to 150 mg of surfactant before declining. The medication was released from the beads for up to 24 hours. In drug release by in-vitro research discovered that the F8 formulation released more than the pure drug. The research will aid in creating a novel dosage form for floating beads.

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